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Summary: The Harris Orthopaedics Laboratory (HOL) at Massachusetts General Hospital, Boston, is a nonprofit preclinical biomechanical research and biomaterials testing lab focused on total joint replacement (TJR) materials and techniques. Led by Orhun Muratoglu, the team develops advanced UHMWPE formulations (including highly-crosslinked, remelted or vitamin E-stabilized variants) to improve implant longevity and reduce osteolysis, aiming to expand TJR use to younger, active patients. HOL also works on non-degradable, hydrogel-based materials for cartilage repair and conducts in vivo follow-up studies and clinical implant performance analyses to provide evidence-based feedback to clinicians. The clinical arm builds local and regional implant registries and conducts prospective studies on alternative bearing materials and new implant designs, collaborating with orthopedic surgeons across arthroplasty, spine, hand, sports medicine, and trauma. Based in Boston, HOL has a small team (about 5 employees) and has operated since 1969, contributing to material science, biomechanics testing, and bench-to-clinic implant development.

Clinic Type

Orthopedics

Address

55 Fruit St, Boston, Massachusetts 02114, US

Phone

617-726-2000

Email

giving@mgb.org

Opening Hours

Not published — contact the clinic to confirm hours.

Services Offered

Team

  • Maurice Albright — MD
  • Kyle Alpaugh — MD
  • Arun Aneja — MD, PhD
  • Peter Asnis — MD
  • Ashwin Babu — MD
  • Hany Bedair — MD
  • Lorena Bejarano Pineda — MD
  • Eric Berkson — MD
  • Abhiram Bhashyam — MD, PhD
  • David Binder — MD

Insurance & Payment

Languages Spoken

Photos

Information sourced from the clinic's website as of July 11, 2026.

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