Best Walk-In Clinic clinics in Charleston, SC.

Roper St. Francis Express Care is the urgent care division of Roper St. Francis Healthcare, a nonprofit health system based in Charleston, SC. It offers fast, walk-in urgent care services in the Charleston area and has earned local recognition (Best Urgent Care by Charleston City Paper 2026). The broader Roper St. Francis network includes hospital-level services (cancer care, heart and vascular, orthopedics, women's services, rehabilitation) and a physician network across multiple South Carolina locations. The organization employs about 1,904 staff, is headquartered at 316 Calhoun Street, Charleston, and traces its roots to 1829.

MUSC Health offers 24/7 urgent care and emergency services, with virtual visits available through the MUSC Center for Telehealth. The Center (founded 2014) is a state-wide telehealth headquarters and a national Telehealth Center of Excellence, enabling expert care access across South Carolina via remote video, store-and-forward, and remote monitoring. Based in Charleston, SC, the Center collaborates with MUSC Health and statewide providers to deliver high-quality urgent and emergency care through telehealth, education, and simulation. Contact: telehealthinfo@musc.edu | 843-792-1414.