Best Orthopedics clinics in Sioux Falls, SD.

Sanford Health is a nonprofit integrated health care system headquartered in Sioux Falls, SD. Sanford Orthopedics and Sports Medicine is part of the Sanford Health network, offering orthopedic and sports medicine services across Sanford locations, including the Sioux Falls campus. Sanford Health operates 8 U.S. offices (including Sioux Falls HQ, Fargo, Bemidji, Bismarck, Marshfield), and serves patients with a broad range of medical services. Contact: 1-605-333-1000. If you’re specifically seeking orthopedic care in Sioux Falls, you’ll find Sanford Orthopedics and Sports Medicine within the Sanford Health system there.

Avera Orthopedic Hospital is part of Avera McKennan Health in Sioux Falls, SD. It sits on the Avera on Louise Health Campus and, as of 2026, reflects the campus’ reorganization with Pavilion 2 housing the Avera Digestive Health Center and related services. Avera McKennan is a nonprofit health system with a broad array of specialties (including orthopedics) and multiple locations across the Upper Midwest. Main contact numbers for the system are listed, and the HQ is in Sioux Falls. Website: locations.avera.org.

Orthopedic Institute (OI) is a private, physician-led medical practice based in Sioux Falls, SD, specializing in orthopedics and sports medicine for nearly 50 years. They offer comprehensive, state-of-the-art musculoskeletal care across neck/spine, shoulder/elbow, hand/wrist, knee, hip, foot/ankle, and related areas, with integrated physical and occupational therapy to relieve pain and speed recovery. OI emphasizes an exceptional patient experience and has a network of 26 offices primarily in the Midwest, including Sioux Falls, Yankton, Mitchell, and outreach locations in South Dakota, Minnesota, and Iowa. They promote convenient access through multiple clinics and partnerships with referring doctors, aiming to help patients “get relief, move better, live stronger.”