Main Street Drug
Pharmacy • Charles City, IA
About
Main Street Drug is an apothecary-style pharmacy in Charles City, Iowa, offering compounding services, COVID/flu and strep testing and treatment, immunizations, diabetic shoes, durable medical equipment, and multi-dose compliance packaging. The pharmacy provides free delivery within 20 miles and is handicapped accessible.
Clinic Type
Pharmacy
Address
204 N Main St, Charles City, IA 50616-2017
Phone
(641) 228-3519
privacy@cencora.com
Opening Hours
Monday 9:00 AM – 5:30 PM CDT; Tuesday 9:00 AM – 5:30 PM CDT; Wednesday 9:00 AM – 5:30 PM CDT; Thursday 9:00 AM – 5:30 PM CDT; Friday 9:00 AM – 5:30 PM CDT; Saturday 9:00 AM – 12:00 PM CDT; Sunday Closed
Services Offered
Insurance & Payment
—
Languages Spoken
Social Media
Photos
What Patients Say
Overall sentiment across review platforms: positive
- Facebook: 100% recommend (based on 16 reviews) (16 reviews)
- Loc8NearMe: Not explicitly provided, but described as generally highly rated by customers (17+ comments/reviews aggregate)
Patients praise
- friendly and helpful staff
- efficient and fast service
- hometown, welcoming atmosphere
- convenient delivery services
- ability to fill hard-to-find medications
Common complaints
- some reports of staff appearing grumpy or short, particularly near opening times
"Main Street Drug is a clean, friendly, and well-organized pharmacy that offers a warm, small-town atmosphere with the conveniences of a larger store. The staff is helpful, personable, and always greeting customers with a smile."
— Loc8NearMe Review Summary"My parents use them for the excellent service. I stopped in to pick up for an emergency situation. They seems grumpy. It was 9 am at opening. Short and too the point. Helpful enough overall."
— Loc8NearMe Review (Dec 2025)Synthesized from public review platforms as of Jul 11, 2026 — sources: [1][2][3][4].
In the News
- Charles City man nabbed with illegal drugs - NorthIowaToday.com — Apr 23, 2026
- Charles City pharmaceutical company expansion to add 104 good-paying jobs - NorthIowaToday.com — May 15, 2026
- Wanted Charles City man nabbed with meth - NorthIowaToday.com — Mar 16, 2026
- Home | Charles City Area Economic Development — Nov 13, 2025
- Minnesota man accused of attempting to deal meth in Charles City - NorthIowaToday.com — Oct 8, 2025
Information sourced from the clinic's website as of July 11, 2026.
More pharmacy clinics in Charles City
Floyd County Medical Center (FCMC) is a 25-bed Critical Access Hospital and Rural Health Clinic in Charles City, Iowa. It provides 24/7 emergency and after-hours acute care, inpatient and skilled nursing care, and a broad range of outpatient services including diabetes management, nutrition, wound/ostomy care, and physical, speech, and occupational therapy. Outpatient specialties cover general surgery, cardiology, ENT, nephrology, orthopedics, podiatry, urology, podiatry, and sleep studies. The center is licensed, accredited, and governed by a seven-member elected Board, with headquarters in Charles City. FCMC also operates a rural health clinic expansion, and is actively growing its services in the region. contact: 641-228-6830.
WIC Clinic - North Iowa Community Action in Charles City provides nutrition support and food assistance to income-eligible pregnant and postpartum women and children under five. Services include breastfeeding education and lactation support, breast pump access, nutrition education from qualified professionals, breastfeeding peer counselor support, and monthly supplemental foods. The clinic also connects families to community resources.
Your clinic’s marketing team, powered by AI.On-brand ads, SEO, and social campaigns in one place.Generate your first clinic ad for free 
Get more revenue from the patients you already have.Voice and SMS that follow up until lapsed patients are back on the schedule.Book a Clincy call 
Your practice’s fractional recruiting team.Dental-only search, run end to end, with placements guaranteed for a year.Find your next hire Comparing your options?
See other pharmacy clinics in Charles City, or search the full directory by insurance, ratings, and more.