Best Oncology clinics in Santa Clarita, CA.

City of Hope in Santa Clarita, CA offers comprehensive cancer care and related services as part of its nationwide network. As a National Cancer Institute-designated comprehensive cancer center, City of Hope combines world-class treatment with pioneering research, clinical trials, and patient-support services. While the main campus is in Duarte, CA, the organization maintains multiple locations and a broader California presence to help patients access advanced cancer therapies, including medical oncology, surgical oncology, radiation oncology, and supportive care. For Santa Clarita specifics, contact or visit the Santa Clarita address on their California network page for local appointments, multidisciplinary care teams, and access to listed cancer treatments and programs.

The UCLA Health Jonsson Comprehensive Cancer Center is UCLA’s cancer care and research hub, offering traditional and experimental cancer treatments across its hospitals, clinics, and school of medicine. It emphasizes cutting-edge care, community outreach, equity, and ongoing cancer research with resources across campus and partner sites. The center is headquartered in Los Angeles and includes affiliated programs such as UCLA Health Santa Clarita Cancer Care, which was recognized in 2026 as a winner of SCV élite Magazine’s Ultimate Medical Awards in oncology. The goal is to deliver focused, best-in-class cancer care and to advance new methods to eliminate cancer, leveraging UCLA’s campus resources, community clinics, and partners.

Henry Mayo Newhall Memorial Hospital (Valencia, Santa Clarita, CA) is a nonprofit, 357-bed community hospital and trauma center founded in 1975. It offers comprehensive cancer care as part of its broad services, including inpatient and outpatient facilities, imaging, lab, infusion, and specialized centers. The hospital features a NICU, Center for Women and Newborns, catheterization lab, breast center, and extensive programs in cardiovascular, emergency/trauma, spine and joint, behavioral health, and rehabilitation. It operates the Sheila R. Veloz Breast Center with advanced detection options and serves the Valencia/Santa Clarita Valley community as an Advanced Primary Stroke Center and STEMI Receiving Center. Headquarters are at 23845 McBean Parkway, Valencia, CA 91355.