Santa Clarita, CA, Cancer Treatment and Care | City of Hope
Oncology • Santa Clarita, CA
About
City of Hope in Santa Clarita, CA offers comprehensive cancer care and related services as part of its nationwide network. As a National Cancer Institute-designated comprehensive cancer center, City of Hope combines world-class treatment with pioneering research, clinical trials, and patient-support services. While the main campus is in Duarte, CA, the organization maintains multiple locations and a broader California presence to help patients access advanced cancer therapies, including medical oncology, surgical oncology, radiation oncology, and supportive care. For Santa Clarita specifics, contact or visit the Santa Clarita address on their California network page for local appointments, multidisciplinary care teams, and access to listed cancer treatments and programs. If you’re seeking treatment details, confirm current services, availability, and referrals at the Santa Clarita site.
Clinic Type
Oncology
Address
23823 Valencia Boulevard, Suite 250 Santa Clarita, CA 91355
Phone
(661) 799-1999
giving@coh.org
Opening Hours
Monday through Friday: 8 a.m. to 5 p.m. Closed on major federal holidays
Services Offered
Insurance & Payment
—
View a list of insurance companies that City of Hope currently contracts with for its locations and physicians. Even if your plan is included, check with your insurance company to make sure you are covered.
Languages Spoken
—
FAQs
What are the operating hours?
Monday through Friday: 8 a.m. to 5 p.m. Closed on major federal holidays.
How can I request an appointment?
Request an Appointment.
What services are available at Santa Clarita City of Hope?
Medical oncology with personalized treatment plans, oral oncolytics, and related supportive care.
Is my insurance accepted?
There is an Insurance Information section with a list of insurance plans City of Hope contracts with; verify coverage with your plan and obtain any necessary authorizations.
How can I contact for help?
Need Help? Contact City of Hope; phone number listed is (661) 799-1999.
Social Media
Photos
What Patients Say
Overall sentiment across review platforms: mixed
- PissedConsumer: 1.6 out of 5 (across broader PissedConsumer network) (20 reviews (broader network))
- LocalityBiz: 5/5 (sample reviews) (Multiple individual positive mentions)
Patients praise
- highly compassionate, supportive, and kind clinical staff
- sense of family-like atmosphere during treatment
- thorough communication and time dedicated to patient questions
- professional and skilled medical teams
Common complaints
- allegations of prioritizing profit over patient care
- concerns regarding communication and administrative follow-up
- reports of perceived negligence or poor clinical outcomes in broader network reviews
"If it weren’t for this group of beautiful people…..I don’t know what I would have done!! They are so nice and mellow. I was scared to death when I first came in…..By the time the first treatment was done…….They felt like family!!!!!"
— LocalityBiz Reviewer"If your loved one has cancer DO NOT come here... all they want is your $$$ they will request ct scan..."
— Yelp User ReviewSynthesized from public review platforms as of Jul 10, 2026 — sources: [1][2][3][4].
In the News
- City of Hope Santa Clarita, Valencia 91355, Santa Clarita CA: Practo — Jul 23, 2025
- SCVNews.com | March 28: Vine2Wine ‘A Mediterranean Toga Affair’ for Circle of Hope | 03-03-2026 — Mar 3, 2026
- Residents gather toga-ther for Circle of Hope’s Vine2Wine — Apr 1, 2026
- Circle Of Hope’s Vine2Wine: A Mediterranean Evening Pouring Hope Into The Santa Clarita Valley — Mar 3, 2026
- Orange County Cancer Treatment Center | City of Hope — Mar 29, 2022
Information sourced from the clinic's website as of July 10, 2026.
More oncology clinics in Santa Clarita
Summary: The UCLA Health Jonsson Comprehensive Cancer Center is UCLA’s cancer care and research hub, offering traditional and experimental cancer treatments across its hospitals, clinics, and school of medicine. It emphasizes cutting-edge care, community outreach, equity, and ongoing cancer research with resources across campus and partner sites. The center is headquartered in Los Angeles and includes affiliated programs such as UCLA Health Santa Clarita Cancer Care, which was recognized in 2026 as a winner of SCV élite Magazine’s Ultimate Medical Awards in oncology. The goal is to deliver focused, best-in-class cancer care and to advance new methods to eliminate cancer, leveraging UCLA’s campus resources, community clinics, and partners.
Henry Mayo Newhall Memorial Hospital (Valencia, Santa Clarita, CA) is a nonprofit, 357-bed community hospital and trauma center founded in 1975. It offers comprehensive cancer care as part of its broad services, including inpatient and outpatient facilities, imaging, lab, infusion, and specialized centers. The hospital features a NICU, Center for Women and Newborns, catheterization lab, breast center, and extensive programs in cardiovascular, emergency/trauma, spine and joint, behavioral health, and rehabilitation. It operates the Sheila R. Veloz Breast Center with advanced detection options and serves the Valencia/Santa Clarita Valley community as an Advanced Primary Stroke Center and STEMI Receiving Center. Headquarters are at 23845 McBean Parkway, Valencia, CA 91355.
Your clinic’s marketing team, powered by AI.On-brand ads, SEO, and social campaigns in one place.Generate your first clinic ad for free 
Get more revenue from the patients you already have.Voice and SMS that follow up until lapsed patients are back on the schedule.Book a Clincy call 
Your practice’s fractional recruiting team.Dental-only search, run end to end, with placements guaranteed for a year.Find your next hire Comparing your options?
See other oncology clinics in Santa Clarita, or search the full directory by insurance, ratings, and more.